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Research Network

PRN™

Praxis Research Network — Clinical Decisions, Designed. Evidence, Governed.

India's multi-centre decision-science network. PRN™ converts routine treatment patterns into statistically governed, publication-grade evidence — at national scale. Mobile-first capture, unified specialty registries, deterministic analysis, and audit-ready governance built for multi-centre reinforcement.

Mobile-first Multi-centre Deterministic Publication-ready Audit-ready
Join the Network → View Specialties Become a Founding Member
PRN™ — Contribution Pipeline
📋
Capture
~45s / entry
→
🔗
Harmonise
Registry
→
📊
Analyse
Deterministic
→
📄
Publish
IMRAD-ready
5 specialties · Phase 1 Registry + pathway study Decision thresholds Audit-ready logs Multi-centre reinforcement
34
Clinical disciplines
5
Phase 1 specialties
45s
Target entry time
100%
Audit-ready outputs
Why PRN Exists

India treats at scale. PRN measures at scale.

Clinical practice generates enormous signal — yet most of it never becomes harmonised evidence. PRN structures routine into research with a governance layer built for reproducibility.

The Problem

Fragmented, siloed, underpowered

Protocols vary across centres, outcomes are recorded inconsistently, and research stays siloed — reducing statistical power and slowing publication cycles. The same clinical decisions are made repeatedly without a systematic feedback loop.

The PRN Approach

Governed capture → governed evidence

Mobile-first structured capture (45s target), unified specialty registries, deterministic analysis, and audit-ready governance — designed for multi-centre reinforcement at the point where routine practice becomes durable evidence.

The Outcome

Publication-grade decision assets

Registry assets and comparative pathway studies that produce publication-grade outputs, decision thresholds, and institutional learning loops — without black-box methods or opaque interpretation.

How PRN Works

A repeatable pipeline from practice to publication.

Fast contribution → harmonised registries → governed analysis → publications and decision refinement. Every step is governed, documented, and audit-ready.

01
Log in ~45 seconds
Tap-based structured entry — minimal typing, standardised fields, specialty-aware pathways. Designed for real OPD workflows without research fatigue.
02
Harmonise across centres
Unified definitions, outcome registry, and consistent follow-up structure enabling multi-centre reinforcement. Same fields, same logic, every centre, every time.
03
Analyse deterministically
Transparent assumptions, explicit diagnostics, and audit-ready logs. No black-box inference. Every analysis step is documented before it runs.
04
Publish & refine decisions
IMRAD-ready templates, effect size emphasis, reviewer-facing appendices. Outputs that extract decision thresholds and feed back into network learning loops.
Design Principles

PRN is a decision-science lab — not a loose collaboration.

Decision-first research

Define the decision before the model

We define the clinical decision, the threshold, and the intended action before modelling — so outputs are operational, not academic artifacts. Every study has a decision output pre-specified.

Deterministic analytics

Transparent, documented, reproducible

Transparent assumptions, explicit diagnostics, and audit-ready logs — no black-box inference. The same inputs always produce the same outputs. Reviewers can interrogate every step.

45-second contribution model

Designed for real OPD workflows

Tap-based, specialty-aware fields designed for real OPD workflows — high compliance without research fatigue. If it takes more than 45 seconds, the form is wrong.

Publication architecture built-in

Reviewer-ready from day one

IMRAD-ready templates, effect size emphasis, reviewer-facing appendices, and structured interpretation geared for clinical decisions. Every registry is designed with its publication in mind.

Capabilities

What PRN™ delivers.

01
Registry Framework
Multi-specialty patient registries with pre-specified endpoints, unified definitions, and tap-based OPD capture. Every registry is audit-ready before the first patient is enrolled.
34 disciplinesPre-specified
02
Comparative Pathway Studies
Each specialty launches with a comparative cohort study alongside its registry. Propensity-adjusted analysis compares real-world treatment pathways on decision-grade endpoints.
Propensity-adjustedDecision outputs
03
Governance & Audit Trail
Deterministic analysis, explicit assumption documentation, pre-specified endpoints, and append-only audit logs. Every PRN study is reviewer-ready before submission.
Audit-readyDeterministic
04
PRN Intelligence Digest™
Monthly specialty-specific decision brief for every member: global signals with effect sizes, India-specific lens, threshold commentary, and one actionable PRN study opportunity per issue.
MonthlySpecialty-specific
05
AURORA™ Integration
AURORA™ converts PRN registry data into structured study portfolios — from clinical capture to publication-ready evidence. Automated study discovery within the PRN data architecture.
Study discoveryPortfolio output
Phase 1 — Study Slate

Five specialties. Two governed studies each.

Each specialty launches with one national registry plus one comparative pathway study — designed for output velocity and durable decision assets. All studies follow PRN governance: definition registry, pre-specified endpoints, audit-ready logs, deterministic analysis.

PRN-RA01 · Registry + Pathways

Treat-to-Target in Rheumatoid Arthritis (Real-World Indian Cohort)

Quantify real-world effectiveness of treat-to-target (T2T) implementation and identify the decision thresholds — activity score bands and escalation triggers — associated with remission and steroid reduction in Indian practice.

Decision output: Recommended escalation trigger bands associated with best outcomes in Indian cohort
DesignProspective multi-centre observational registry (rolling enrolment)
CaptureDisease activity bands, steroid exposure, escalation, biologic/DMARD category, adverse events, follow-up cadence
Primary outcomeRemission/low-activity status at 6–12 months (band-based endpoint)
PRN-RA02 · Comparative Pathway

Early Biologic Escalation vs Step-Up Conventional Therapy

Compare two real-world escalation pathways — early biologic escalation vs step-up conventional DMARD strategy — on disease control and steroid dependence.

Decision output: Practical escalation pathway guidance for Indian real-world settings
DesignMulti-centre comparative observational cohort (pathway-defined)
AnalysisPropensity score weighting/matching; subgroup analyses by baseline severity band
Primary outcomeAchievement of low-activity/remission band at 6 months
PRN-ENDO01 · Registry

Type 2 Diabetes Real-World Control Trajectories (Indian Practice Registry)

Map real-world glycaemic control trajectories and determine which treatment sequencing patterns are associated with durable HbA1c improvement in Indian routine care.

Decision output: Sequencing patterns linked to best outcomes by baseline HbA1c band
DesignProspective registry (multi-centre, rolling)
CaptureHbA1c band, BMI band, therapy category, escalation, hypoglycaemia flag, follow-up band
Primary outcomeImprovement to lower HbA1c band at 3–6 months
PRN-ENDO02 · Comparative Pathway

Early SGLT2/GLP-1 Introduction vs Conventional Step-Up

Compare early introduction of modern agents (SGLT2/GLP-1 class) vs conventional step-up approaches on glycaemic band shift and hypoglycaemia risk.

Decision output: Practical intensification trigger recommendations by starting HbA1c band
DesignMulti-centre comparative observational cohort (pathway-defined)
AnalysisPropensity adjustment; subgroup by baseline HbA1c band; outcomes at 3–6 months
Primary outcomeHbA1c band improvement at 6 months
PRN-OPH01 · Registry

Diabetic Retinopathy & DME Outcomes Registry (Real-World India)

Establish a multi-centre outcomes registry for DR/DME and quantify real-world vision and OCT-response patterns under routine anti-VEGF/care pathways.

Decision output: Cadence bands associated with best outcomes in Indian practice
DesignProspective registry (multi-centre)
CaptureVisual acuity band, OCT status band, treatment category, injection cadence band, adherence proxy
Primary outcomeVisual acuity band improvement at 3–6 months
PRN-OPH02 · Comparative Pathway

Fixed Schedule vs PRN Anti-VEGF Protocol

Compare fixed injection schedules vs PRN protocols on visual outcome bands and recurrence under real-world adherence constraints.

Decision output: Protocol guidance balancing outcomes vs burden under Indian follow-up realities
DesignComparative observational cohort (protocol-defined)
AnalysisPropensity adjustment; subgroup analyses by baseline acuity band and adherence band
Primary outcomeVisual acuity band improvement at 6 months
PRN-PULM01 · Registry

Asthma/COPD Exacerbation & Control Registry (India)

Quantify real-world control and exacerbation patterns and build a practical decision layer for follow-up cadence and escalation triggers.

Decision output: Escalation triggers by severity and exacerbation history bands
DesignProspective registry (multi-centre)
CaptureDiagnosis, severity band, exacerbation frequency, hospitalization flag, therapy category, adherence proxy
Primary outcomeExacerbation frequency band at 3–6 months
PRN-PULM02 · Comparative Pathway

Dual Therapy vs Triple Therapy in Moderate COPD

Compare dual therapy vs triple therapy pathways in moderate COPD on hospitalisation rates, exacerbation frequency, and therapy burden.

Decision output: Triple therapy escalation trigger by severity and exacerbation band
DesignMulti-centre comparative observational cohort (therapy-pathway defined)
AnalysisPropensity adjustment; subgroup by severity band and baseline exacerbation history
Primary outcomeHospitalisation rate and exacerbation frequency band at 6 months
PRN-GYN01 · Registry

High-Volume Gynaecology Longitudinal Registry

Establish a multi-centre high-volume gynaecology registry capturing routine OPD patterns to support pathway effectiveness studies and subgroup stratification.

Decision output: Pathway effectiveness evidence and stratified subgroup insights for Indian gynaecology practice
DesignProspective high-volume longitudinal registry (multi-centre)
CaptureCondition category, therapy category, follow-up cadence, outcome bands, adverse event flags
Primary outcomeCondition-specific outcome band improvement at 3–6 months
PRN-GYN02 · Comparative Pathway

Pathway Effectiveness — Stratified Subgroup Study

Compare two common management pathways in a high-volume gynaecology condition on outcome bands, follow-up adherence, and adverse event rates across stratified subgroups.

Decision output: Pathway preference guidance by patient subgroup for Indian clinical settings
DesignMulti-centre comparative observational cohort (pathway-defined)
AnalysisPropensity adjustment; subgroup analyses by age band, parity band, and comorbidity flags
Primary outcomeOutcome band improvement and adverse event rate at 3–6 months
Monthly PRN Intelligence Digest™

Not a newsletter. A decision brief.

Every member receives a specialty-specific monthly brief curated by Ayati's decision-science team — short, practical, and decision-oriented. Designed for busy clinicians. Read in minutes. Apply in practice.

🌐
Global Update
5–7 global signals, effect size first

Key trials and practice signals summarised as "what changed" and "how big the change is" — not just p-values. Effect sizes and confidence intervals always reported.

📐
Decision Angle
Threshold commentary

What decision thresholds may shift — initiation, escalation, follow-up cadence — and what cautions apply before changing practice based on the month's signals.

🇮🇳
India Relevance
Local cohort lens

Why results may differ in Indian practice contexts — adherence patterns, follow-up realities, comorbidity profiles, and real-world constraints not captured in trial settings.

🔬
PRN Opportunity
Study trigger

One actionable PRN-ready study idea derived from the month's global signals and local practice variability. The engine that keeps the research pipeline continuously generative.

Specialty-specific per member Governed interpretation Includes caveats & limitations One actionable PRN study trigger per issue
Membership Model

Selective free founding cohort, followed by structured expansion.

Hybrid rollout — establishing credibility and early publications first, then paid structured expansion. Three tiers for different contributor profiles.

Founding Cohort

Limited Founding Member

Year 1 complimentary · Invitation only
For high-volume super-specialists & progressive partner hospitals
Founding member recognition in all PRN publications
Priority authorship pathway
Governance advisory input
Early access to specialty registries
Monthly PRN Intelligence Digest™
Request Invitation
Individual Specialist

Join as Contributor

Subscription
Single-doctor mode → multi-centre studies through PRN chapters
Registry participation
Study enrolment eligibility
Monthly Digest subscription
Publication participation rules
Data-quality feedback loop
Join PRN
Institutional Partner

Multi-Doctor Onboarding

Tiered · Hospitals & clinics
Multi-doctor onboarding at institution level
Definition harmonisation support
Governance toolkit
Multi-centre comparative studies
Institutional visibility in PRN outputs
Request Partnership
Governance Principles

Audit-ready, reproducible research — outputs designed for clinical decisions.

P1
Define before modelling

All metrics, endpoints, and thresholds are codified before any data analysis begins

P2
Document before inference

Assumptions and diagnostics are recorded explicitly before drawing any conclusions

P3
Log before publication

Audit-ready logs are created and retained for every study at every stage

P4
Design for audit

Every registry and study is structured so a reviewer can independently validate the evidence

P5
Interpret for decision

Outputs target actionable thresholds, not academic artifacts. Interpretation is clinical

Build India's Clinical Decision Intelligence Grid

Join PRN to contribute
structured real-world evidence.

Participate in multi-centre studies and receive specialty-specific decision briefs. Powered by Ayati Analytics. Decision-first, not tool-first.

Join PRN™ Institutional Partnership